Readers with access to the medical literature can find these arguments elaborated in the writings of Donald Klein of Columbia University, particularly Quitkin FM, Klein DF, "What Conditions Are Necessary to Assess Antidepressant Efficacy?" Archives of General Psychiatry 57: 323-324, 2000. Similar analyses can be found in Klein DF, Thase E, et al., "Improving Clinical Trials," Archives of General Psychiatry 59: 272-278, 2002; Quitkin FM, Rabkin JG, et al., "Validity of Clinical Trials of Antidepressants," American Journal of Psychiatry 157: 327-337, 2000; and Klein DF, "Improvement of Phase III Psychotropic Drug Trials by Intensive Phase II Work," Neuropsychopharmacology 4:251-258, 1991.