In my post yesterday on why you shouldn't give money to an exclusive American college or university, I suggested instead that your money might be better used by the Against Malaria Foundation. That was an example I used because the last time I checked, the AMF was GiveWell's top-ranked charity. As a number of people pointed out to me, this is no longer the case and GiveWell recently decided to stop recommending AMF, essentially because it's not clear that AMF currently has the capacity to use more money effectively.
GiveWell's new No. 1 choice is GiveDirectly, which I've written about several times before and is just great. Not unrelated to this, one advantage of the GiveDirectly concept is that it's a lot easier to see a path forward for endless scaling.