Future Heart Attack Treatments Will Use Light, Not Volts, to Keep Your Heart Beating

Future Tense
The Citizen's Guide to the Future
Aug. 30 2013 4:44 PM

Future Heart Attack Treatments Will Use Light, Not Volts, to Keep Your Heart Beating

In this illustration, the “optrode” at left delivers blue light to the heart via a fiber-optic tip. At right, a heart cell (large red oval) contains an implanted light-sensitive “opsin” protein (blue oval) that works alongside the heart’s own proteins (yellow ovals). This teamwork allows the cell to convert light energy into an electric kick that triggers a healthy heartbeat.

Graphic courtesy of Patrick M. Boyle

Electricity is as blunt a tool as we have in our medical arsenal. Whether it’s an implanted pacemaker or defibrillator paddles on the chest—CLEAR!—using electricity to kick-start a heart feels like getting kicked by a Clydesdale. We use it because it works, but we can’t stop all those volts from ripping through surrounding flesh and bone. Scientists call this a global electrical response, and it does a number on the human body, from killing cells to disrupting the heart’s normal rat-a-tat rhythm. And that’s why a team at Johns Hopkins University is experimenting with a lighter approach.

Literally. Through an emerging field called optogenetics, they plan to use a fancy blue light to coax the heart out of its funk.


“Wouldn’t it be amazing to shine a light on somebody who’s having a heart attack and you’re able to restore their life?” muses Natalia Trayanova, the Murray B. Sachs professor of biomedical engineering at Johns Hopkins University. “We’re far from that, but just the idea of that is really driving this research.”

It sounds fantastical—more like something out of Men in Black than modern medicine—but the study of optogenetics has already made great strides in neuroscience. Now, Trayanova and her team aim to expand the field to cardiology.

Here’s how it works. The scientists start by inserting light-responsive proteins, called opsins, into individual cells. When exposed to the proper intensity of blue light, the opsins react by opening gateways to the heart’s natural electrical impulses, thus jump-starting the rhythm. A defibrillator works in the same way, though instead of unlatching the gate politely, it charges through like Raiden on a combo.

Treating the heart with this method would also allow medical professionals to target specific areas in need of a low-energy jolt, instead of bathing the whole body in electrical bedlam.

Trayanova and her colleagues are currently testing opsins on an extremely sophisticated computer model of the heart in order to determine the most productive avenues to explore with live flesh. Not only does the model let them see how opsins might perform from the individual cell level on up to the heart as a whole, but in the future it could allow doctors to tailor optogenetic solutions for individual patients.

Since normal human heart cells don’t have opsins, optogenetics won’t be applicable for every patient who comes into an emergency room clutching his or her chest—and we’re likely still a decade away from having this as a treatment option. But for people with increased risk of heart disease or a history of heart attack, this technology has the potential to save lives and improve their quality. “It should be completely painless,” Trayanova told me. 

While there’s clearly a lot of work left to do, one thing is certain: As optogenetic heart treatments come closer to reality, you’re going to see a whole slew of headlines talking about lightsabers

Future Tense is a partnership of SlateNew America, and Arizona State University.

Jason Bittel serves up science for picky eaters on his website, BittelMeThis.com. He lives in Pittsburgh. Follow him on Twitter.



Forget Oculus Rift

This $25 cardboard box turns your phone into an incredibly fun virtual reality experience.

The Congressional Republican Digging Through Scientists’ Grant Proposals

The 2014 Kansas City Royals Show the Value of Building a Mediocre Baseball Team

The GOP Won’t Win Any Black Votes With Its New “Willie Horton” Ad

Whole Foods Is Desperate for Customers to Feel Warm and Fuzzy Again

The XX Factor

I’m 25. I Have $250.03.

My doctors want me to freeze my eggs.

The XX Factor
Oct. 20 2014 6:17 PM I’m 25. I Have $250.03. My doctors want me to freeze my eggs.

Smash and Grab

Will competitive Senate contests in Kansas and South Dakota lead to more late-breaking races in future elections?

I Am 25. I Don’t Work at Facebook. My Doctors Want Me to Freeze My Eggs.

These Companies in Japan Are More Than 1,000 Years Old

  News & Politics
The World
Oct. 21 2014 11:40 AM The U.S. Has Spent $7 Billion Fighting the War on Drugs in Afghanistan. It Hasn’t Worked. 
Oct. 21 2014 1:12 PM The Global Millionaires Club Is Booming and Losing Its Exclusivity
The Vault
Oct. 21 2014 2:23 PM A Data-Packed Map of American Immigration in 1903
  Double X
The XX Factor
Oct. 21 2014 1:12 PM George Tiller’s Murderer Threatens Another Abortion Provider, Claims Right of Free Speech
  Slate Plus
Behind the Scenes
Oct. 21 2014 1:02 PM Where Are Slate Plus Members From? This Weird Cartogram Explains. A weird-looking cartogram of Slate Plus memberships by state.
Brow Beat
Oct. 21 2014 1:47 PM The Best Way to Fry an Egg
Oct. 21 2014 10:43 AM Social Networking Didn’t Start at Harvard It really began at a girls’ reform school.
  Health & Science
Climate Desk
Oct. 21 2014 11:53 AM Taking Research for Granted Texas Republican Lamar Smith continues his crusade against independence in science.
Sports Nut
Oct. 20 2014 5:09 PM Keepaway, on Three. Ready—Break! On his record-breaking touchdown pass, Peyton Manning couldn’t even leave the celebration to chance.