The scifi blog io9 has an interesting idea: the next Trek series should focus on a grown-up Wesley Crusher who captains a starship that goes around the Alpha Quadrant solving mysteries (like how Janeway got a command, or why Worf always pops up anywhere in the galaxy he's needed).
I actually think this isn't a bad idea. Wesley was irritating, but he was written and directed that way. Wil is actually a fine actor and it would be cool to see him doing this. I suspect he wouldn't be interested, to be honest, but since he does sometimes pop up in the comments here, we'll see. Keep your eyes on his blog to see if he has anything to say.
And hmmm. He'd need a science/astronomy advisor...
P.S. Coincidentally, Gina Trapani at Lifehacker just wrote up a short piece about Wil.
Tip o' the VISOR to Dave Hall for pointing this out... before I actually got to io9 in my feed reader today. :-)