Slate turns 10 this week, and we're publishing The Best of Slate: A 10th Anniversary Anthology. In celebration of the book and the anniversary, we're publishing (or, rather, re-publishing) a selection of pieces from the anthology, including this article. This article was originally published Jan. 2, 2001. You can see a list of all the republished pieces, as well as everything else we are publishing in honor of the anniversary, here.
Download MP3 audio of Seth Stevenson reading this story here, or sign up for Slate's free daily podcast on iTunes.
Day 8: Delayed orgasm, beyond a reasonable point, is not a good thing. I will say nothing further about this.
Day 11: Side effects have mostly faded out, save for the orgasm thing, which is in for the long haul. I'm not seeing any personality changes, though. At a party a few nights ago (among good friends, so not a worthy testing ground), I did notice one thing: After a few drinks, I began to discourse freely on my Paxil experience.
Generally, talking about myself, even with close friends, is my least favorite thing to do (writing about myself is clearly a different [2,000-word] story). So this was odd. But was it the Paxil? The alcohol? Or just that, for a change, I had something to talk about?
II. The Unexamined Life
Day 16: Still no visible change. However, I can't get a lick of work done. Unfinished articles are lying around, waiting for my attention. Motivation has dried up. Coincidence?
Day 25: A pattern is emerging. Since starting on Paxil, I've been drinking like a fish. For some reason, vitamin P combines incredibly well with alcohol. It's more fun to drink than it was before. I want to be drunk every night. I don't get hung over now, and I remain pretty lucid even when sloshed.
Day 27: Paxil is messing with my livelihood. I'm still not getting any work done. Could it be Paxil's antidepressant effects? Perhaps I'm too content to be motivated. Do I require bile and unhappiness to write? I could clearly go the rest of my life on this stuff and never feel down again.
Another scary part: Before Paxil, while working on stories, turns of phrase would pop into my head, fully formed. Lying awake at night, or riding on the subway, poof—a neat arrangement of words would appear from nowhere. And would often show up in the article. It's part of what makes writing fun and surprising. On Paxil, it's gone. The words just aren't coming.
Also, the last few days I've considered cutting down on free-lancing and getting a regular job—consulting or something. Previously, I couldn't imagine a job like this. Regular hours and no creative outlet sounded like a nightmare. All wrong for me. But now, stability, routine, and boredom sounds A-OK. Pleasant, even. An easy way to make a buck and just live my life.
Day 29: A literati book party. My first real test, and it's basically a failure. Upon meeting a gaggle of strangers, I still sprout flop sweat all over my torso, just like before. I still can't introduce myself to people I'd like to meet. I still don't know how to talk in big groups.
But then something magical happens. After deciding Paxil is worthless and downing three glasses of wine, I find I want to talk to people. No, it wasn't the alcohol. I drink at parties all the time—and go from standing alone in the corner to standing drunk and alone in the corner. This time, I'm craving conversation. In fact, I want to talk about myself. And in the midst of a lively monologue delivered to a group of four people (previously unimaginable for me), I recognize the feeling: It's like being on ecstasy! Relaxed, exceedingly comfortable with strangers, completely open. It makes some sense—both drugs noodle with your serotonin. Paxil, like Prozac and Zoloft, is a selective serotonin reuptake inhibitor. SSRIs block reabsorption of serotonin—a neurotransmitter—by your nerve endings, boosting serotonin levels in your brain. Ecstasy tweaks up your serotonin, too. But instead of paying $20 for a night on E, I paid $15 for a month on P. The catch: I seem to require alcohol as a trigger. Not sure why, and I doubt my doc could explain it.