What do the E. coli outbreaks of 2006 tell us about the limits of bioterrorism?

The state of the universe.
March 19 2008 12:07 PM

Spinach, Lettuce, and the Limits of Bioterrorism

A comforting look back at the major E. coli outbreaks of 2006.

(Continued from Page 1)

The scientists concluded that at some point in the not-too-distant past, this strain of E. coli O157:H7 evolved rapidly into a far meaner pathogen than its ancestors. Natural selection altered its genes quickly, thanks to the ability bacteria have to reproduce in as little time as 20 minutes. Speeding up their evolution even further was their ability to take in DNA from other microbes, even from species that are only distantly related. The genomes of bacteria are being continually rejiggered into new combinations of genes. Some bacteria become better at capturing sunlight, others at resisting antibiotics. And, in the case of the spinach strain of E. coli O157:H7, the introduction of viral DNA has made them far nastier.

It is chilling to think just how quickly a new, more dangerous form of E. coli has emerged—and it's tempting to think that its quick arrival bodes ill for synthetic biology. After all, if it just takes a few years for a dangerous strain to evolve in the wild, just think how easy it will be for people to build them in the lab.

Advertisement

In fact, the spinach outbreak teaches a very different lesson. The Michigan State scientists have no idea what is making the new strain so mean. It's a straightforward task to identify the hundreds of new genes in its genome, but the researchers can't say precisely what all those new genes are doing. The same goes for the hundreds of missing genes as well as for the other genes tweaked and fine-tuned by natural selection.

This sort of ignorance is par for the course in the world of microbes. And if a new strain of an intensely studied species is so mysterious, it's hard to believe that bioterrorists could just type out a new plague on their keyboards. Our deep ignorance also raises some doubts about how far synthetic biologists can go with the good applications of the science. In the most ambitious projects, scientists have inserted only a few genes. They've had some spectacular successes, such as making E. coli produce jet fuel and precursors to malaria medicine. But the notion that we might add hundreds of genes to bacteria to do something useful, like turn microbes into solar power generators, may be hubris for a long time to come.

Inventors don't always design their inventions from scratch, though. Perhaps someone could create a new pathogen simply by mimicking nature: combining different sets of genes, mutating a few of them, and using trial and error to find ones that worked? Probably not. Nature's lab bench is colossal. Millions of cattle and other animals are carrying around E. coli O157:H7, and an incalculable number of viruses are invading them, trying out new combinations. Many of those combinations turn out to be failures, but natural selection can give rise to a few spectacular successes. Even if a government built a giant lab just for the purpose of stumbling across a new pathogen, it might take centuries or millenniums to hit on something like the spinach strain.

But this ignorance is not cause for much comfort. Even if we don't need to worry about synthetic bacteria just yet, we do need to worry about new pathogens evolving right in our own backyard (or, rather, our own feedlots and factory farms). As things stand, we become vaguely aware of these bacteria only once they've been sickening and killing for years. One way to speed up the search for nature's new bioweapons would be to set up a monitoring network. If public-health workers were equipped with cheap, fast testing devices, E. coli and other microbes might not be able to surprise us so often in the future. And if some evil genius does someday figure out how to unleash a bioweapon, we will have had an excellent rehearsal.

TODAY IN SLATE

History

The Self-Made Man

The story of America’s most pliable, pernicious, irrepressible myth.

Michigan’s Tradition of Football “Toughness” Needs to Go—Starting With Coach Hoke

Does Your Child Have “Sluggish Cognitive Tempo”? Or Is That Just a Disorder Made Up to Scare You?

The First Case of Ebola in America Has Been Diagnosed in Dallas

Windows 8 Was So Bad That Microsoft Will Skip Straight to Windows 10

Politics

Mad About Modi


Why the controversial Indian prime minister drew 19,000 cheering fans to Madison Square Garden.


Building a Better Workplace

You Deserve a Pre-cation

The smartest job perk you’ve never heard of.

Don’t Panic! The U.S. Already Stops Ebola and Similar Diseases From Spreading. Here’s How.

Parents, Get Your Teenage Daughters the IUD

The XX Factor
Sept. 30 2014 12:34 PM Parents, Get Your Teenage Daughters the IUD
  News & Politics
Politics
Sept. 30 2014 6:59 PM The Democrats’ War at Home Can the president’s party defend itself from the president’s foreign policy blunders?
  Business
Moneybox
Sept. 30 2014 7:02 PM At Long Last, eBay Sets PayPal Free
  Life
Gaming
Sept. 30 2014 7:35 PM Who Owns Scrabble’s Word List? Hasbro says the list of playable words belongs to the company. Players beg to differ.
  Double X
The XX Factor
Sept. 30 2014 12:34 PM Parents, Get Your Teenage Daughters the IUD
  Slate Plus
Behind the Scenes
Sept. 30 2014 3:21 PM Meet Jordan Weissmann Five questions with Slate’s senior business and economics correspondent.
  Arts
Brow Beat
Sept. 30 2014 8:54 PM Bette Davis Talks Gender Roles in a Delightful, Animated Interview From 1963
  Technology
Future Tense
Sept. 30 2014 7:00 PM There’s Going to Be a Live-Action Tetris Movie for Some Reason
  Health & Science
Medical Examiner
Sept. 30 2014 6:44 PM Ebola Was Already Here How the United States contains deadly hemorrhagic fevers.
  Sports
Sports Nut
Sept. 30 2014 5:54 PM Goodbye, Tough Guy It’s time for Michigan to fire its toughness-obsessed coach, Brady Hoke.