Do birth control pills make women gain weight?

Health and medicine explained.
Aug. 17 2011 6:59 AM

Baby Fat

Do birth control pills make women gain weight?

Illustration by Alex Eben Meyer. Click image to expand.

Some women are getting pregnant to avoid getting fat. According to a review published in a recent issue of the journal Contraception, concern about weight gain is among the most common reasons people quit the pill (or decide not to take it in the first place), and most women who discontinue the pill switch to something less effective or nothing at all. Some of those women end up with unintended pregnancies simply because they feared a few extra pounds.

The notion that birth control pills make you fat is just part of what the paper's lead author, physician David Grimes of the University of North Carolina, calls an elaborate mythology, one "fueled by rumor, gossip and poor-quality research." As it turns out, there's never been convincing evidence that the pill in any of its forms provokes weight gain. Another recent review paper found little evidence of weight gain among users of progestin-only pills, and a similar study from 2008 likewise failed to find any connection between weight gain and pills that contain progestin and estrogen.

Some studies hint that the pill might even have the opposite effect. According to a 1997 study, users of birth control pills have a basal metabolic rate almost 5 percent higher than people who have never used the pill, and a small 2009 trial concluded that the pill reduced body fat in women who took it. A study published last year tracked nearly 500 women aged 15 to 19 over several years and found that while all the teens gained some weight, those who used birth control pills gained about a pound less than those who didn't. (Young women who used injectable hormonal contraceptives like Depo-Provera did pack on extra weight—they gained twice as much, on average, as everyone else.)

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If the pill doesn't cause weight gain, how did it get its reputation? Chalk up some of it to folklore about hormones, which are regularly blamed—sometimes with just cause—for everything from moodiness to bloating and breast tenderness. It's not just sexist thugs who joke that female hormones make women bitchy and unappealing around their cycles; plenty of women make PMS jokes, too. The pill is often said to mimic pregnancy, and everyone knows that pregnant women experience huge changes to their bodies, including additional pounds.

Perhaps the most powerful factor in the spread of misinformation is the pill packets themselves. The labels of most oral contraceptives list "weight gain" among their common side effects. If the drug companies themselves are telling us that the pill makes us fat, why shouldn't we believe them? The warnings on the label are not always so trustworthy; in many cases, they're simply a function of the quirky way in which side effects are reported in clinical trials. Participants are asked to report any symptoms they notice during the study, and those that turn up most often may end up being listed even if there's no proof they were caused by the medication.

As a result, almost any trial will turn up an array of what doctors call "nonspecific" symptoms—vague complaints that do not signal a specific condition. "They're the aches and pains of daily life," Grimes says, things like headaches and moodiness and, yes, weight gain. Weight gain is especially pervasive—the average adult gains about a pound per year—so even if people taking a medication do put on a few pounds, it's hard to pin the effect on a particular drug. Medications proven to cause weight gain, like antidepressants, antipsychotics, allergy medications, and steroids generally lead to much greater increases in body weight.

The only way to know whether a symptom already prevalent in everyday life is provoked or made worse by a drug is to do a controlled trial in which women are randomly assigned to take either contraceptive pills or a placebo. It's tricky to recruit women for the placebo arm of a birth-control trial, but researchers have managed to complete three such studies, involving a total of more than 1,200 women total. These were designed to test the pill's ability to reduce acne or menstrual pain, but the researchers also gathered data on rates of headache, nausea, breast tenderness, vomiting, and weight gain. They found no significant differences in any of these among women who took birth control pills and those who got a placebo. (The pill's most common side effects are, in fact, spotting and bleeding in between periods.

The perceived link between birth-control pills and weight gain actually goes back to America's very first contraceptive, a combination pill called Enovid. When Enovid was approved as a contraceptive in 1960, it came with a booklet noting that "weight gain or loss occurs occasionally. If you should gain weight and it is objectionable to you, control your diet and use less salt." Indeed, many women thought that Enovid was making them gain weight but stayed on it anyway because they loved having spontaneity in their sex lives without the worry of pregnancy, says Andrea Tone, author of Devices and Desires: A History of Contraceptives in America.

It's not clear whether Enovid, which contained a far greater dose of hormones than today's pills, actually made women plump, but once the idea that it provoked weight gain took hold, it became a self-fulfilling prophecy. The power of suggestion is extraordinarily potent, and telling women that the pill might cause weight gain (or nausea or breast tenderness) can make those side effects appear. Scientists call this the nocebo effect. We know that expecting a sugar pill to improve your health can invoke a beneficial placebo response, but expectation works the other way, too. Ask people to remain alert for a symptom, and they're more likely to see it. In one study from 2007, about 100 Italian men with prostate problems were given a commonly-prescribed drug, and half were told that the drug might cause erectile dysfunction and loss of libido. The patients who had been warned about side effects ended up experiencing them at a much higher rate than the ones who never heard about them.

So here's the question: If telling a woman that she might gain weight could actually make her gain weight, why don't the doctors and pharmaceutical companies just keep their mouths shut? Grimes argues that to prevent nocebo responses, nonspecific symptoms like weight gain should be removed from all drug labels unless or until they've been definitively linked to the drug. That's unlikely to happen anytime soon, though. The FDA offers drug companies guidance on which potential side effects to list on a label, and manufacturers tend to go ahead and list any that have shown up in clinical trials regardless of whether they're caused by the drug in question. That way, they can tell any patients who decide to sue that they had been warned.

About half of pregnancies in the United States are unplanned. The pill is not right for every woman, and it has small but important risks, such as the potential for life-threatening blood clots. Even so, taking the pill is safer than being pregnant. Studies also show that women on the pill have significant reductions in the risk for endometrial and ovarian cancers (along with tiny, probably insignificant increases in the risk of cervical and liver cancers). And if you really want to stay trim, birth control pills are a good way to go. When taken as directed, the pill is about 99 percent effective in preventing pregnancy, which is perhaps the world's most reliable cause of weight gain. "About 25 to 30 pounds quite predictably," says Grimes.

Christie Aschwanden is an award-winning writer and contributing editor for Runner's World. She blogs about science at Last Word on Nothing.

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