Deep brain stimulation as a treatment for depression.

Health and medicine explained.
Feb. 19 2008 5:24 PM


Is it a good idea to drill holes in people's heads to treat them for depression?

(Continued from Page 1)

Despite this early encouragement, there are reasons to be cautious. Parkinson's researchers were able to induce and treat tremors in animals before embarking on DBS in humans. But animal research on depression doesn't really work, because we don't know how to measure animals' mental states. That means human trials from the outset. The two major ones proceeding so far are being sponsored by companies—St. Jude Medical and Medtronic—that make the implants and so have a vested interest in the results. The legacy of psychosurgery is not exactly reassuring, either. DBS may be a far cry from the days when lobotomies robbed patients of the ability to feel emotions like love and compassion. But not long ago, patients receiving ECT suffered serious memory loss.

It's also unsettling that scientists can't account for why the patients in the small initial studies felt better—or why some showed dramatic changes and others improved only slightly or not at all (although no one got worse). Theories abound about whether the DBS voltage changes the firing pattern in the brain or affects a larger depression "circuit" that other treatments can't reach.There are no data on the long-term risks of continuous stimulation, and it's uncertain if the results could be replicated on a larger scale. "This is certainly not yet ready for prime time," says Mayberg, who has enrolled 20 more people in her study. DBS also carries a 1 percent to 2 percent risk of intracranial hemorrhage and a 5 percent to 10 percent risk of infection or a malfunctioning pacemaker. At the highest voltage, some patients temporarily felt lightheaded or mentally slow. Also, there's the potential for brain damage from gliosis (the brain's version of scar tissue), which can develop around the contact points.


At the same time, autopsies of Parkinson's patients who received DBS implants revealed no significant changes in the areas around the electrode contacts, according to Cleveland Clinic neurosurgeon Dr. Ali Rezai. He also points out that his depressed subjects tested the same in terms of cognitive functioning before and after getting implants. In some cases, the current even improved their memories. (Again, scientists don't know why.)

On balance, the FDA is right to move forward with this precarious research. The history of antidepressant drugs is full of examples of treatments that scientists didn't—and still don't—precisely understand and that nonetheless have brought relief to millions of people. And unlike other neurostimulation therapies for depression on the market or in development, the brain pacemaker has a track record. Some 40,000 people worldwide have undergone DBS, mostly for Parkinson's and other movement disorders. Researchers testing it for mental illness say they follow strict protocols by admitting only subjects who have tried and failed to respond to numerous rounds of drugs, psychotherapy, and ECT. In other words, like a lot of people willing to try experimental treatments, these patients have less to lose.

None of this means, however, that DBS is likely to be used to treat depression on a wide scale. Researchers currently are looking for brain markers that might flag which patients would respond best to it. The treatment also isn't a cure-all, and patients may need to supplement it with more traditional talk therapy. Meanwhile, neurologists are exploring the use of brain pacemakers to treat drug addiction, anorexia, obesity, Tourette's syndrome, and obsessive-compulsive disorder. We have to simultaneously become more comfortable with poking around in people's brains without letting ourselves forget just how mysterious and delicate this all is.



Forget Oculus Rift

This $25 cardboard box turns your phone into an incredibly fun virtual reality experience.

The Congressional Republican Digging Through Scientists’ Grant Proposals

Renée Zellweger’s New Face Is Too Real

Sleater-Kinney Was Once America’s Best Rock Band

Can it be again?

Whole Foods Is Desperate for Customers to Feel Warm and Fuzzy Again

The XX Factor

I’m 25. I Have $250.03.

My doctors want me to freeze my eggs.

The XX Factor
Oct. 20 2014 6:17 PM I’m 25. I Have $250.03. My doctors want me to freeze my eggs.

Smash and Grab

Will competitive Senate contests in Kansas and South Dakota lead to more late-breaking races in future elections?

George Tiller’s Murderer Threatens Another Abortion Provider, Claims Free Speech

Walmart Is Crushing the Rest of Corporate America in Adopting Solar Power

  News & Politics
The World
Oct. 21 2014 3:13 PM Why Countries Make Human Rights Pledges They Have No Intention of Honoring
Oct. 21 2014 5:57 PM Soda and Fries Have Lost Their Charm for Both Consumers and Investors
The Vault
Oct. 21 2014 2:23 PM A Data-Packed Map of American Immigration in 1903
  Double X
The XX Factor
Oct. 21 2014 3:03 PM Renée Zellweger’s New Face Is Too Real
  Slate Plus
Behind the Scenes
Oct. 21 2014 1:02 PM Where Are Slate Plus Members From? This Weird Cartogram Explains. A weird-looking cartogram of Slate Plus memberships by state.
Brow Beat
Oct. 21 2014 1:47 PM The Best Way to Fry an Egg
Oct. 21 2014 5:38 PM Justified Paranoia Citizenfour offers a look into the mind of Edward Snowden.
  Health & Science
Climate Desk
Oct. 21 2014 11:53 AM Taking Research for Granted Texas Republican Lamar Smith continues his crusade against independence in science.
Sports Nut
Oct. 20 2014 5:09 PM Keepaway, on Three. Ready—Break! On his record-breaking touchdown pass, Peyton Manning couldn’t even leave the celebration to chance.